I agree that for holiday visitors taking both of these would be a good idea if they plan to bareback. I know that acyclovir is used to limit herpes infections and can also used used full time, at lower dosages, to limit or prevent outbreaks. I'm purely speculating that if you took a full dose of acyclovir for 1-2 weeks while on holiday that it 'might' prevent you from getting herpes. The drug stops the herpes virus from replicating But I don't know if it would actually stop a person from getting the infection initially. I'm old so I remember back in the 70's, where there was no HIV and not much talk about herpes. We screwed like crazy and the worst thing I ever got was the 'drip', Gonorrhea that was easy cleared up by a shot of penicillin or taking some pills for a few days. Those were the days of Sex, drugs, and rock-n-roll. Sex was carefree, fun, and usually free. Times have changed.