To be perfectly honest...
- Automatic car, you are pretty much fine driving with 1 arm/1 leg/whatever. Manual, well...quite a bit more hassle.
- You are deaf. Bit harder but kind of irrelevant. Chances are you are listening to music anyway and your windows are closed, although I keep my ears open, I don't need them to drive. Ambulances are hit or miss, I usually seem them before I can hear them, for whatever reason, Ambulances here seem to transmit their sirens at whisper volume.
- Colorblind also doesn't matter. Traffic lights are (even for Thais) standardized, red on top, green on the bottom. Traffic signs are unique with a meaning, colors don't matter, though a helpful reminder.
- 1 eye. That's a tough one due to losing depth perception, can be managed but needs a working brain along with drivings most important skill, situational awareness.
- Blind. Get a taxi.