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cormanr7

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About cormanr7

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  • Birthday 10/10/1955

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  1. But it remains to be seen what will happen when vector vaccines have to be injected regularly. This may lead to 'anti-vector immunity'. People will not have immunity to a chimp cold virus when first injected but this may change after several injections. Sputnik tries to reduce this problem by using different vectors in the first and second shot. However, it may be necessary in the longer term to use a mRNA or protein vaccine after a viral vector vaccine. Whereas a viral vector has been used in a recent Ebola vaccine, there has been a huge failure in the past with Merck's HIV vaccine where (quo
  2. Indeed. Well, once the 30,000 person ENSEMBLE2 trial is finished -where Janssen tests the efficacy of two shots rather than one- things may change. Trial details here: https://clinicaltrials.gov/ct2/show/NCT04614948. There are some differences between the three vial vector vaccines with respect to the vector used: chimp in AZ, human Ad26 then Ad5 in Sputnik and Ad26 in Janssen.
  3. It does not have to be a pill. There is a phase I trial in India (by Codagenex in partnership with Serum Institute) with a nasal spray, with another company expected to start a trial in the US shortly. A major reason to use they sprays is not to convince hardcore antivaxxers, but reduce/prevent SARS-CoV-2 replication in the nose. More details here: https://www.biospace.com/article/intranasal-approaches-have-potential-as-vaccines-and-therapies-for-covid-19/. Potential advantages are they might be attractive for people who are scared of injection needles or have blood clotting disorders. Also it
  4. In addition to data from the UK, results from a large scale study in Israel -which only uses the BioNTech-Pfizer vaccine- involving ca 600,000 people have now been published (Dagan et al. 2021: https://www.nejm.org/doi/full/10.1056/NEJMoa2101765. (At least) one week after the 2nd injection, effectiveness against various outcomes such as symptomatic disease, hospitalization, severe disease was in the range of 87-94%. There are lots more data, including effect of a single shot. For some useful comments and potential shortcomings of the study, check the following: https://www.sciencemediace
  5. I have been looking at flights to Europe (via Doha) in May/June 2021. Plenty listed on the Qatar website, with -presently- two departures listed from BKK. Situation is very fluid however, can change -for better or worse- at any moment. Note that with limited flights, stopover time can be long, so choose carefully!
  6. Actually, the UK govt. reports the number of 'yellow cards'. These are obtained from a site where people can self-report side effects after COVID vaccination https://coronavirus-yellowcard.mhra.gov.uk/. The data are not really very recent but for the period up to Feb. 7th, there were 3-4 yellow cards per 1,000 vaccinations for both AZ and Pfizer vaccines https://www.gov.uk/government/publications/coronavirus-covid-19-vaccine-adverse-reactions/coronavirus-vaccine-summary-of-yellow-card-reporting. Not sure how many people are actually using the site, numbers might be (grossly?) underestimat
  7. This is a hotly contested topic and nobody knows for sure. A recent piece of research suggests that the magnitude of an infection-induced immune response varies a lot between individuals but lasted for at least 5-8 months. This study is a bit more encompassing than many others and does not focus on one part of the immune system like IgG or IgA but also measures various types of T-cells, etc.: https://science.sciencemag.org/content/371/6529/eabf4063 Note that this is an in vitro, small study conducted in the US.
  8. Major problem is getting reliable data (or even any data) on effectiveness/safety of some of the vaccines. The Chinese vaccines as well as the Sputnik V are used to a large extent in (let's keep it polite) 'authoritarian' countries where asking questions or criticising anything can land you in hot water. Apart from that, it is not so easy to distinguish between effect of vaccination and lockdown measures. In many countries, there is now a sharp drop in cases/deaths irrespective whether they have an advanced vaccination program or not. The UAE is currently in 2nd place when it comes to vac
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