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Oxx

Hydroxychloroquine is useless

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Yes, it doesn't look promising. What may help till a vaccine is here is convalescent antibody therapy. Survivors plasma is separated and low dosed into folks for the antibodies it contains. It has shown success in the past with other viruses. imo a magic bullet is not going to appear till trials are finished on vaccines though I understand why people are reaching for these types of straws..

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In my latest post I referred to this Paris study as the "French follow-up". The study design was better than the Marseille study. 

 

Another recent randomised study (not French),  also scientifically sound, found some efficacy, statistically significant. (Improvement with drugs in about 25 cases versus about 17 in the placebo group - treatment was begun early, when the patients were still doing ok)

All these studies are small.

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Chloroquine/HCQ is being investigated because it has well known antiviral activity in vitro.

Nothing to do with antiinflammatory properties. 

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Posted (edited)

One more data point. There are some issues with this study:

 

1. It was much smaller with just 9 patients completing the study.

2. 8 patients had  "significant co morbidities associated with poor outcomes".

3. They did not look for a decrease in viral load, the used PCR to detect its presence.

4. Their results only measured if it had disappeared or not after 5 days.

 

Yes it is a data point, but one of the weakest so far. Cholorquine will not treat comorbidities.

Edited by rabas
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22 minutes ago, from the home of CC said:

Yes, it doesn't look promising. What may help till a vaccine is here is convalescent antibody therapy. Survivors plasma is separated and low dosed into folks for the antibodies it contains. It has shown success in the past with other viruses. imo a magic bullet is not going to appear till trials are finished on vaccines though I understand why people are reaching for these types of straws..

Plasma hasn't proven all that effective, these people are using computer simulations to modify antibodies from SARS-CoV epidemic in 2003, might be more effective and is in test phase: 

 

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6 minutes ago, DrTuner said:

Plasma hasn't proven all that effective, these people are using computer simulations to modify antibodies from SARS-CoV epidemic in 2003, might be more effective and is in test phase: 

 

It is not a cure all but possibly will give time to patients to allow them to live long enough to produce their own antibodies.  

https://www.latimes.com/science/story/2020-04-02/blood-centers-begin-collecting-coronavirus-antibodies-from-covid-19-survivors

 

The kicker is that this can be tried now. The world can't afford to wait out researchers without at least trying something that has worked before..

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45 minutes ago, Oxx said:

Despite some individuals (most notably the President of the United States of America) having suggested that hydroxychloroquine is effective against the virus, despite only anecdotal evidence for this, it has now been demonstrated that it is ineffectual.  

 

"No Evidence of Rapid Antiviral Clearance or Clinical Benefit with the Combination of Hydroxychloroquine and Azithromycin in Patients with Severe COVID-19 Infection" - Molina et al. (2020)

 

https://doi.org/10.1016/j.medmal.2020.03.006

i think (not being a doctor) the thread title is incorrect, and your understanding of the study title may be as well.

 

there have been studies showing a correlation between use of hyd+azi being effective in treatment, so there is some evidence.  this was one study among many attempting to confirm it.

 

this study used a very small sample so the value of any findings would be limited.  the extract even stated further investigation would be required for a definitive answer.

 

as the study title stated, THIS trial found no evidence, not that there was no evidence showing the combination of drugs to be promising.  as they stated, other studies have suggested efficacy.

 

this study did not demonstrate the drug to be ineffectual; it was unable to demonstrate the drug to be effectual.  that's my understanding.

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Strange, i read case studies from Belgium and France and it seemed successful, but it doesn't matter really anyway as we can't get hold of any

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Seems to me folks don't want there to be a "natural" aid to help fight & recover, Vit C, Zinc, Lysine and any thing else that is natural is deemed useless as is the body's immune system! Stopping people taking the sun especially in the West is ludicrous!

People will only be happy when "Big Pharma" save the day, strange times..........................

What on earth has happened to the world that we now have to rely on "others" to save us! Are we no longer able to live in a "natural" world? 🤔

End times? 

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