New COVID-19 infections in Thailand are highly contagious G viral strain – Dr. Yong

[CALSinCM]

2 hours ago, smedly said:

this is complete bull

 

and from a country who have no clue how many have been infected or died because they don't test

But, but, but...that's the point isn't it?
No tests, no infections!

"Welcome To Squeaky Clean, Infection-free Thailand!"

There's the bill of goods. 

[Clarkey611]

5 hours ago, yuyiinthesky said:

To my astonishment I have not found that any scientist has isolated the SARS-CoV-2 Virus yet. All this panic caused by PCR tests which nobody can really say what they test for. 
 

As in the PCR test patented by Germany‘s Drosten, based on RNA fragments found in the lungs of 4 early Chinese patients, maybe a virus, maybe whatever. Not tested against the virus, as it was never isolated. No Gold-Standard. This is not science, this is gambling.

 

Which tests are used? Are they validated? You think so? Well sorry, they are not. No isolated Virus, no virus confirmed by the main criteria, Koch's postulates. Validation thus impossible, not even attempted.

 

But be scared. Shut down. Stay home. After all it was in the news, it must be true.

Just reviewed a project last week out of Vietnam using a RNS extraction to a RT-PCR. 2 reactions to detect the N gene segment of the coronavirus, together with the internal control detection to control the quality from the RNS extraction. The project has been a great success. More interestingly the project was started in mid December 2019, so where did they get the information about the problem at that time?

[Guderian]

The mild strain was the one that originally affected Thailand in January and didn't do much damage. Then in March we had the Thai superspreader who'd just returned from northern Italy and infected 80 people with the G  strain in one evening at the Lumpini muay Thai stadium. So yes, of course we'll have to deal with the G strain in a new wave, but we've already dealt with it once, stick with the same protocols and beef up the testing and we should be fine. Oh, and don't forget to plug the porous borders, lol. 

[yuyiinthesky]

54 minutes ago, Guderian said:

Oh, and don't forget to plug the porous borders, lol. 

Why? Zero infections in the neighboring countries, Laos, Cambodia, even Vietnam. Vietnam and Cambodia have kind of reopened already to let children living on one side of the border go to school on the other side of the border. You cannot spread any infection if you‘re not infected.

[Mung]

and yesterday people were slating me for pointing out that there are more virulent strains out there. I repeat, Thailand hasn't had it's full on pandemic yet 

[Mung]

and yesterday people were slating me for pointing out that there are more virulent strains out there. I repeat, Thailand hasn't had it's full on pandemic yet 

[Mung]

9 hours ago, Bkk Brian said:

Mild symptoms can still make you extremely sick with long term health problems.

My 30 year old neighbour still cannot breathe properly, and she has only really regained the ability to walk 

[Starmocihc]

10 hours ago, spiekerjozef said:

That is the US strategy, infect everybody.

And they are doing a stunning job to achieve that.

Downside: you might lose a few....

 

Few, sure, some, perhaps. But still far less than the US has lost to suicide from year to year. 2020 will bring a record loss due to suicide, it will shadow the true virus "count."

[kingofthemountain]

11 hours ago, Jingthing said:

This is so insidious. One loose infectious person and we're off to the races. 

Some categories of foreigners coming from abroad are exempted from the mandatory quarantine

and it could be a problem very soon

 

Edited July 13, 2020 by kingofthemountain

[Letseng]

3 hours ago, rabas said:

He is not saying the new G strain leads to less severe cases. He's not talking about decreased live viral particle shedding in patients.  Rather, he sees  less shedding of the S1 protein (one small piece of the spike) from his test-tube experiments, suggesting the S protein structure is more stable.

 

Increased S protein stability leads to greater infectivity because  there is more S protein available, not because the S protein attacks the ACE2 receptor better. Same old bullets just more of them. See here. He also shows the new S protein should not be any more susceptible to antibodies and does not suggest it is less severe. A couple comments from the paper:

 

(Fig. 1b), indicating a transmission advantage over viruses with D614. Korber et al. noted that this change also correlated with increased viral loads in COVID-19 patients[22]

An interesting question is why viruses carrying the more stable SG614 appear to be more transmissible without resulting in a major observable difference in disease severity[22,27]

 

So, it's basically the same old virus but now on a Ducati rather than a Honda Wing.

 

 

Everyday I follow the no. of new cases. Don't see arriving Europeans on the list nor Thais returning from continental Europe. So how many infected Europeans did this good doctor actually get to test to see the new strain? Sounds more like keep foreigners out.

[Letseng]

1 hour ago, yuyiinthesky said:

Why? Zero infections in the neighboring countries, Laos, Cambodia, even Vietnam. Vietnam and Cambodia have kind of reopened already to let children living on one side of the border go to school on the other side of the border. You cannot spread any infection if you‘re not infected.

how do you know you are not infected? Kids rarely show symptoms, adults don't always show symptoms but spread far & wide. Just had such a cluster in our local Rotarians. 23 out of 26 meeting participants infected by one person on one evening. Was not in Thailand. 2 doctors amongst them.

[hotchilli]

16 hours ago, Jingthing said:

This is so insidious. One loose infectious person and we're off to the races. 

Everything starts with the first one>

 

[GoodieAfterDark]

[morrobay]

11 hours ago, rabas said:

He is not saying the new G strain leads to less severe cases. He's not talking about decreased live viral particle shedding in patients.  Rather, he sees  less shedding of the S1 protein (one small piece of the spike) from his test-tube experiments, suggesting the S protein structure is more stable.

 

Increased S protein stability leads to greater infectivity because  there is more S protein available, not because the S protein attacks the ACE2 receptor better. Same old bullets just more of them. See here. He also shows the new S protein should not be any more susceptible to antibodies and does not suggest it is less severe. A couple comments from the paper:

 

(Fig. 1b), indicating a transmission advantage over viruses with D614. Korber et al. noted that this change also correlated with increased viral loads in COVID-19 patients[22]

An interesting question is why viruses carrying the more stable SG614 appear to be more transmissible without resulting in a major observable difference in disease severity[22,27]

 

So, it's basically the same old virus but now on a Ducati rather than a Honda Wing.

 

 

Perhaps it is too soon to answer the  question about disease severity in the D614G genotype. At a later date based on selection pressurs it should be shown that in addition to increses infectivity there will also be data to support decrease lethality.. 

Ok I read the paper more carefully .But  I only  said the change in protein structure from D614G incresed the number of binding sites ,

not that 'S1 attacks ACE2 better'

So since the S1S2 structue is more stable (as explained in the paper)  there is less S1 shedding and more S1 available for adhesion to the ACE2  host  receptor.

I would suggest that with the S1 spike protein being more stable, in addition to more S1, for binding to host ACE2 ( hydrogen or ionic bonds between the COO- and NH3+ groups  on the respective amino acids) would be favored. 

Edited July 14, 2020 by morrobay

[spidermike007]

19 hours ago, Anton9 said:

https://time.com/5842669/coronavirus-asymptomatic-transmission/

There is alot of debate about asymptomatic transmission. Yes? No? Most experts do not know. And nearly all asymptomatic infections show as positive for Covid. Even early on. 

[Rimmer]

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[Deli]

I'm more exited by a G Syring on a girl than by a G Strain which I cannot see

[John CS]

30 minutes ago, Deli said:

I'm more exited by a G Syring on a girl than by a G Strain which I cannot see

Humour debunks , but predictive texts kill all 

[Rimmer]

A post discussing moderation has been removed

[yuyiinthesky]

20 hours ago, Letseng said:

how do you know you are not infected? Kids rarely show symptoms, adults don't always show symptoms but spread far & wide. Just had such a cluster in our local Rotarians. 23 out of 26 meeting participants infected by one person on one evening. Was not in Thailand. 2 doctors amongst them.

Your reply has nothing to do with my post.
 

My post was a reply to a comment about Thailand‘s borders, and I said that there are no new infections in the neighboring countries, Laos, Cambodia, even Vietnam. If you disagree, please bring that up with the governments of these countries, which report zero new (not imported) infections for weeks and months by now. Your rotarians have nothing to do with that.

 

Therefore there is no need to keep the land borders between Thailand and these infection free countries closed. The situation in these neighboring countries is as good or better than in Thailand.

[unblocktheplanet]

If you're outside Thailand, don't expect to visit anytime soon!

[Xi Tha Virus]

CCP Virus originated in Wuhan P. R. china.

[KiiGiam]

There is so much here that one can comment on and I would prefer to be talking about the bars,  but it is important to point out a few things here.  1) There is thus far, only ONE "strain" of this virus.  There are several isolates, but only one strain.  2) Mutation means a change in base pairs.  That change may not even change the reading codon, let alone the eventual proteins that are made from this.   All viruses mutate and actually SAR CoV-2 mutates more slowly than other RNA viruses because it contains a self-correcting mechanism in replication that most of the other RNA viruses lack.  3) Most mutations do not result in any change the ability of the virus to infect cells nor in its virulence (how severe it is).  4)  All that investigators have shown (and barely!) is that some cells that are different from cells in the body and in a different environment are more easily infected by the isolate with this mutation.  5) Being able to infect a cell like that does not mean it is better at infecting cells in the human body and it does not mean that the virus is more "transmissible."   This virus is ALREADY very transmissible.  6) Even if it is even more transmissible, it doesn't mean that it is more severe nor dangerous.   7) There is no proof that this isolate is more common now because it outcompetes another isolate for transmission.  It can be that someone with this isolate became the "founder" of spread (so it is called the founder effect) and -that- is why it has become more common in some areas.     **Sorry to go on like this, but this report is completely a mess.