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Pitt scientists say new drug discovery could treat and prevent COVID-19

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8 minutes ago, steelepulse said:

Early days, yet good news.  


Thanks for posting this, but could you cut n' paste the WTAE.com article here? That website is not available to those of us outside America.

 

Edited by Poet
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Mostly biochemical jargon, but confirms what the OP stated:

 

"Novel COVID-19 therapeutics are urgently needed. We generated a phage-displayed human antibody VH domain library from which we identified a high-affinity VH binder ab8. Bivalent VH, VH-Fc ab8 bound with high avidity to membrane-associated S glycoprotein and to mutants found in patients. It potently neutralized mouse adapted SARS-CoV-2 in wild type mice at a dose as low as 2 mg/kg and exhibited high prophylactic and therapeutic efficacy in a hamster model of SARS-CoV-2 infection, possibly enhanced by its relatively small size. Electron microscopy combined with scanning mutagenesis identified ab8 interactions with all three S protomers and showed how ab8 neutralized the virus by directly interfering with ACE2 binding. VH-Fc ab8 did not aggregate and did not bind to 5300 human membrane-associated proteins. The potent neutralization activity of VH-Fc ab8 combined with good developability properties and cross-reactivity to SARS-CoV-2 mutants provide a strong rationale for its evaluation as a COVID-19 therapeutic."

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2 minutes ago, Pottinger said:

Mostly biochemical jargon, but confirms what the OP stated


Yeah, sounds promising.

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TLDR:

Selecting from a massive library of bacteriophages, they are finding the ones that prime your antibodies to target the Coronavirus, to prevent you developing Covid-19 if exposed to it or, if you already have Covid-19, to boost your body's ability to fight it.

So, both a prophylactic and a treatment.

 

Edited by Poet

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2 minutes ago, Mavideol said:

enjoy the reading 41 pages


Thank you, but isn't that the paper from Cell.com? That is available internationally and I had already read it.

Is the blocked WTAE.com article just the same paper?

Again, thank you, I appreciate the effort.

 

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I was able to get the text of the WTAE.com article via a proxy, but not the accompanying video:

Pitt scientists say new drug discovery could treat and prevent COVID-19

News conference touting 'scientific breakthrough in COVID-19 drug development' scheduled for Tuesday

PITTSBURGH —

Scientists at the University of Pittsburgh School of Medicine say they have identified a small molecule that neutralizes SARS-CoV-2, the coronavirus that causes COVID-19.

They say it's a small piece of an antibody, and that it has been used to construct a drug that might be used to treat or even prevent COVID-19.

Pitt scientists worked with colleagues from several other universities and published their findings in the journal Cell on Monday. They say the drug -- Ab8 -- prevents and treats coronavirus infection in mice and hamsters, and there are good indications that it could eventually be used to treat people.

"Ab8 not only has potential as therapy for COVID-19, but it also could be used to keep people from getting SARS-CoV-2 infections," said Dr. John Mellors, chief of the Division of Infectious Diseases at Pitt and UPMC. "Antibodies of larger size have worked against other infectious diseases and have been well tolerated, giving us hope that it could be an effective treatment for patients with COVID-19 and for protection of those who have never had the infection and are not immune."

A UPMC-backed company is licensing Ab8 for development around the world. A timeline wasn't immediately clear.

Mellors and other UPMC and Pitt leaders were expected to discuss more details at a news conference on Tuesday afternoon.

 

Edited by Poet

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10 minutes ago, Poet said:


Thank you, but isn't that the paper from Cell.com? That is available internationally and I had already read it.

Is the blocked WTAE.com article just the same paper?

Again, thank you, I appreciate the effort.

 

the article refers to the one by Cell

 

PITTSBURGH —

Scientists at the University of Pittsburgh School of Medicine say they have identified a small molecule that neutralizes SARS-CoV-2, the coronavirus that causes COVID-19.

They say it's a small piece of an antibody, and that it has been used to construct a drug that might be used to treat or even prevent COVID-19.

Pitt scientists worked with colleagues from several other universities and published their findings in the journal Cell on Monday. They say the drug -- Ab8 -- prevents and treats coronavirus infection in mice and hamsters, and there are good indications that it could eventually be used to treat people.

"Ab8 not only has potential as therapy for COVID-19, but it also could be used to keep people from getting SARS-CoV-2 infections," said Dr. John Mellors, chief of the Division of Infectious Diseases at Pitt and UPMC. "Antibodies of larger size have worked against other infectious diseases and have been well tolerated, giving us hope that it could be an effective treatment for patients with COVID-19 and for protection of those who have never had the infection and are not immune."

A UPMC-backed company is licensing Ab8 for development around the world. A timeline wasn't immediately clear.

Mellors and other UPMC and Pitt leaders were expected to discuss more details at a news conference on Tuesday afternoon.

 

9 v

 

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1 minute ago, Mavideol said:

the article refers to the one by Cell


Yes, thanks again 🙂


 

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4 minutes ago, Poet said:

I was able to get the text of the WTAE.com article via a proxy, but not the accompanying video:

Pitt scientists say new drug discovery could treat and prevent COVID-19

News conference touting 'scientific breakthrough in COVID-19 drug development' scheduled for Tuesday

PITTSBURGH —

Scientists at the University of Pittsburgh School of Medicine say they have identified a small molecule that neutralizes SARS-CoV-2, the coronavirus that causes COVID-19.

They say it's a small piece of an antibody, and that it has been used to construct a drug that might be used to treat or even prevent COVID-19.

Pitt scientists worked with colleagues from several other universities and published their findings in the journal Cell on Monday. They say the drug -- Ab8 -- prevents and treats coronavirus infection in mice and hamsters, and there are good indications that it could eventually be used to treat people.

"Ab8 not only has potential as therapy for COVID-19, but it also could be used to keep people from getting SARS-CoV-2 infections," said Dr. John Mellors, chief of the Division of Infectious Diseases at Pitt and UPMC. "Antibodies of larger size have worked against other infectious diseases and have been well tolerated, giving us hope that it could be an effective treatment for patients with COVID-19 and for protection of those who have never had the infection and are not immune."

A UPMC-backed company is licensing Ab8 for development around the world. A timeline wasn't immediately clear.

Mellors and other UPMC and Pitt leaders were expected to discuss more details at a news conference on Tuesday afternoon.

 

48 seconds video just saying exactly the same as it's written below

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Fantastic news if it proves to be safe and effective in actual treatments for humans.

But way premature to pop the champagne. 

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1 minute ago, Mavideol said:

48 seconds video just saying exactly the same as it's written below


Yeah, I guess some people prefer just watching the video 😄

BTW, I really hate how the EU have effectively broken the Internet by forcing the GDPR on nations over which they should have no juristiction.

Not only have a bunch of useful websites simply decided to block all traffic from outside the US, but we now all have to keep clicking those bloody permission boxes for cookies.

Has anyone ever actually read the details or refused permission? I'm pretty sure everyone just instally presses Okay. In twenty years, millions of people will have RSI thanks to that stupid law.

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12 minutes ago, Jingthing said:

Fantastic news if it proves to be safe and effective in actual treatments for humans.


Sounds like it would be. Fairly simple mechanism. They could be certain that bacteriophages themselves wouldn't cause any damage, and I presume they can be produced at scale. I would imagine they would use some sort of inhaler to get them into your body.

I am guessing this will end up being used as a treatment rather than a prophylactic for the general population. It is unlikely the effect on the antibodies would last long enough for this to be practical as a form of vaccine. So, yeah, probably just something that they would dose the sick with, in addition to a number of other treatments they've discovered over the past few months, all slightly increasing the odds of survival.

At a certain point, with deaths already plummeting, you have to wonder whether all the current extreme measures are really necessary. If they can scale up this and the other treatments, it might be time to recognize that the lockdowns are going to end up causing more death and misery than Covid.

 

Edited by Poet

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Everyone knows that the first one to come up with the vaccine will make like billions in profits almost immediately...

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