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Efficacy of vaccines may reduce after mass inoculation – Dr. Yong


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Efficacy of vaccines may reduce after mass inoculation – Dr. Yong

 

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The efficacy of any vaccine, including COVID-19 vaccines, tends to be lower when used in the field to inoculate millions of people, when compared to the results produced during clinical trials, said Thai virologist Dr. Yong Poovorawan in his Facebook post on Friday.

 

He cited the case of a Hepatitis B vaccine, which its manufacturer claimed had efficacy of between 94-95%. When the vaccine was used in mass inoculations, however, its efficacy dropped to about 80%.

 

Likewise, he said, the 95% efficacy of a COVID-19 vaccine, asclaimed by Pfizer during the trial period, is likely to drop due to several variables.

 

Full story: https://www.thaipbsworld.com/efficacy-of-vaccines-may-reduce-after-mass-inoculation-dr-yong/

 

 

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1 hour ago, Sheryl said:

"And then what you see after mass administration is effectiveness under real world conditions."

But no indications at all so far that Thailand is even contemplating mass administration.

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1 hour ago, Sheryl said:

in clinical trials, protocols are meticulously followed - no mistakes in administration of the vaccine (vaccine reconstituted with exactly the recommended type and amount of solvent, exact amount given exactly as recommend) , no varying from the recommended schedule.

You mean like the dosage stuff up by Astra Zeneca during trials?

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2 hours ago, FarFlungFalang said:

You mean like the dosage stuff up by Astra Zeneca during trials?

You mean the dosage "stuff up" that showed that if you gave a different dosage in the initial shot, you could vastly improve the effectiveness of the vaccine? Yes, it is called serendipithy. As in life, science is full of it. Isn't it wonderful?

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26 minutes ago, Proboscis said:

You mean the dosage "stuff up" that showed that if you gave a different dosage in the initial shot, you could vastly improve the effectiveness of the vaccine? Yes, it is called serendipithy. As in life, science is full of it. Isn't it wonderful?

That's what happened in this case and you might call it serendipity but had the mistake caused harm to many we would call it stupidity instead then it would not be wonderful,which is why we don't normally rush vaccine approvals as in this case.Wonderful to rely on dumb luck?

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On 1/22/2021 at 9:26 PM, FarFlungFalang said:

As I understand the Chinese vaccine Sinovac (which is still to be peer reviewed) has 50.4% efficacy so any significant drop would put them under the 50% cut off required by the WHO.

whatever who require is not relevant because they lie about most things...if china says its 50%, it probably doesnt work at all... like so much china exports!!!

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We just have to wait and see what happens after tons of people has been vaccinated.

Hopefully it wont mutate to much before that, and we're still able to bring it under control. 

 

If Manaus in Brazil is what we should expect to see in the future it's depressive. They thought they had herd immunity last year, but are having a major outbreak once again and people are getting sick a second time. 

 

https://science.sciencemag.org/content/371/6527/329?utm_campaign=toc_sci-mag_2021-01-21&et_rid=714521026&et_cid=3638463

 

I cross my fingers the vaccines do the trick and at least the mRNA vaccines are fast to reprogram to new mutations compared to the old school type vaccines. 

 

If this continues for years to come I need drugs for depression.... 

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The one nice thing is that the rich expats could maybe get a trip to their home countries

and get some other form of vaccine. Right?  The Thailand population except for the

very rich who could also go somewhere else for a shot, will get what they will get.  Ain't

life just grand!   I guess the 2 weeks at each end of the trip may be a slight bummer for

the travellers.  Darn.  I will just be happy to get a vaccine, when Canada gets some Moderna

or maybe eventually more Phyzer  product, which may happen some time this coming Summer.

Geezer

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22 minutes ago, Stargrazer9889 said:

The one nice thing is that the rich expats could maybe get a trip to their home countries

and get some other form of vaccine. Right?  The Thailand population except for the

very rich who could also go somewhere else for a shot, will get what they will get.  Ain't

life just grand!   I guess the 2 weeks at each end of the trip may be a slight bummer for

the travellers.  Darn.  I will just be happy to get a vaccine, when Canada gets some Moderna

or maybe eventually more Phyzer  product, which may happen some time this coming Summer.

Geezer

Not if the airlines won't let you fly without first having the vaccination like many are contemplating.

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3 hours ago, Virt said:

If Manaus in Brazil is what we should expect to see in the future it's depressive. They thought they had herd immunity last year, but are having a major outbreak once again and people are getting sick a second time. 

An interesting comparison is Brazil and Indonesia both countries straddle the equator yet enormous differences in their numbers.I know Brazil has more people living in colder area than Indo but then Japan also has a colder climate yet far fewer deaths.

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7 minutes ago, jak2002003 said:

Not if the airlines won't let you fly without first having the vaccination like many are contemplating.

Before airlines go the no vax no fly route it should be established that the vaccines prevent transmission otherwise the spread will continue and the NVNF will achieve nothing.  

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3 minutes ago, FarFlungFalang said:

An interesting comparison is Brazil and Indonesia both countries straddle the equator yet enormous differences in their numbers.I know Brazil has more people living in colder area than Indo but then Japan also has a colder climate yet far fewer deaths.

Just need to look at the Brazilian diet to see the defining factor.

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27 minutes ago, FarFlungFalang said:

An interesting comparison is Brazil and Indonesia both countries straddle the equator yet enormous differences in their numbers.I know Brazil has more people living in colder area than Indo but then Japan also has a colder climate yet far fewer deaths.

The biggest difference between these countries is that Asia was infected earlier with a much slower spreading 'D' strain. The West was affected from the get go with the much faster  spreading 'G' strain.

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5 minutes ago, rabas said:

The biggest difference between these countries is that Asia was infected earlier with a much slower spreading 'D' strain. The West was affected from the get go with the much faster  spreading 'G' strain.

Also so we are still in the middle of this thing so we will have to see how it pans out and see what happens in Asia if/when they get hit with the newer strains. 

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1 hour ago, FarFlungFalang said:

Also so we are still in the middle of this thing so we will have to see how it pans out and see what happens in Asia if/when they get hit with the newer strains. 

Yes, we'll see. The strain from Myanmar is a descendent of the early, faster spreading Western 'G' strain that passed through India.

 

Because of the recent rise of even newer mutations, we may be in the middle or even early part of the global pandemic. Now they worry that lower efficacy vaccines and also delaying a second dose could increase mutations because many people would have partial immunity.  A worrisome summary from  AAAS's Science:

 

New mutations raise specter of ‘immune escape’

 

I hope Thailand has second thoughts about relying on the lowest quality vaccines from China.

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37 minutes ago, rabas said:

Yes, we'll see. The strain from Myanmar is a descendent of the early, faster spreading Western 'G' strain that passed through India.

 

Because of the recent rise of even newer mutations, we may be in the middle or even early part of the global pandemic. Now they worry that lower efficacy vaccines and also delaying a second dose could increase mutations because many people would have partial immunity.  A worrisome summary from  AAAS's Science:

 

New mutations raise specter of ‘immune escape’

 

I hope Thailand has second thoughts about relying on the lowest quality vaccines from China.

From my sceptical view of "big pharma" I can see them rubbing there hands together at the thought of more profits.

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2 hours ago, FarFlungFalang said:

From my sceptical view of "big pharma" I can see them rubbing there hands together at the thought of more profits.

 

I think it gets ugly when drugs are priced way to high and the profit is not reasonable, but so far I'm not seeing that in any of the vaccines prices. 

 

I think all of them are within a very reasonable price range. 

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